Therapeutic vaccine candidates making use of viral vectors encoding LMP2 have correctly induced virus-particular CD8⁺ T cell responses in early-stage scientific trials. Furthermore, adoptive T cell therapies like posoleucel also goal LMP2 alongside other latency proteins including EBNA1, reinforcing its importance being a conserved and immunodominant antigen.
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EBNA-3a–deficient LCLs proliferate a lot more slowly and gradually and exhibit improved apoptosis as compared to wild-style virus–derived LCLs.
This peptide pool is a really perfect Software for: Characterizing patient-certain or vaccine-induced T cell responses
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